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プレタール SSS ペースメーカー
Q.何故シロスタゾールは、SSS(Sick Sinus Syndrome:洞不全症候群)に使用されるのか?

A.詳しい作用機序は未だ不明。ある程度の論文が散見されており、代表例を紹介する。

  • Title;Efficacy of PDE III inhibitor Cilostazol in sick sinus syndrome.
  • Author;KATO RIN'YA(Nagoyaekisaikaibyoin Junkankika)
  • Journal Title;Japanese Journal of Clinical and Experimental Medicine
  • VOL.83;NO.9;PAGE.1383-1387(2006)

以下、文献アブストラクト
Cilostazol was started on 5 bradycardic patients at 100 mg/day. After the observation of self-defined symptoms, such as facial flush, as well as bradycardia, the dose was increased to 200 mg. We examined efficacy of cilostazol in patients expecting to undergo artificial cardiac pacemaker implant. Cilostazol was effective in improving type-1 and type-2 sick sinus syndrome. As a result, the patients with type-1 and type-2 sick sinus syndrome were able to avoid the artificial pacemaker implant. However, cilostazol induced heart failure when it was used on type-3 sick sinus syndrome patients.

どうやら、タイプ1、2のSSSには有効(ペースメーカー植込みを回避)のようだが、タイプ3には禁忌(心不全を惹起)のため、専門医以外での処方は慎重にされたし。


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Last-modified: 2010-04-16 (Fri) 00:57:51 (JST) (3739d) by msh